13abeta-Berbine, 2,3,9,10-tetramethoxy-, hydrochloride (8CI)
d-tetrahydropalmatine
CAS: 6024-83-5
Molecular Formula: C21H26ClNO4
13abeta-Berbine, 2,3,9,10-tetramethoxy-, hydrochloride (8CI) - Names and Identifiers
13abeta-Berbine, 2,3,9,10-tetramethoxy-, hydrochloride (8CI) - Physico-chemical Properties
| Molecular Formula | C21H26ClNO4 |
| Molar Mass | 391.88844 |
| Physical and Chemical Properties | This product is colorless or light yellow flake crystal, odorless, slightly bitter taste. Melting point 147-149 ℃. In case of light color gradient depth. Easily soluble in ether, chloroform, soluble in ethanol, almost insoluble in water or alkali solution. Its hydrochloride is light yellow crystal, odorless, slightly bitter taste, easy to deteriorate when heated by light. Soluble in water, slightly soluble in ethanol, chloroform, slightly soluble in ether. Alkaloids are extracted from the rhizome of Huangteng, and then hydrogenated. Figure 1 is the molecular structure of tetrahydropalmatine. |
13abeta-Berbine, 2,3,9,10-tetramethoxy-, hydrochloride (8CI) - References
| Pharmacological effects | Tetrahydropalmatine, also known as tetrahydropalmatine, is a kind of alkaloid with analgesic effect isolated from the traditional Chinese medicine Corydalis (Corydalisam-bigua). Tetrahydropalmatine has two enantiomers. L-rotator has an antagonistic effect on dopamine, and D-rotator has no affinity for dopamine receptors, but dopamine stored at nerve endings can be emptied from neurons. Tetrahydropalmatine is a central nervous system inhibitor, which has analgesic, sedative, hypnotic and stable effects. Internal administration is easy to absorb and has a fast analgesic effect. Its analgesic effect is weaker than pethidine (dolantin), but it is stronger than general antipyretic analgesics. It has a good effect on chronic persistent blunt pain and a poor effect on trauma and postoperative pain. It has a certain inhibitory effect on breathing in large doses. It has no obvious effect on liver function and no adverse effect on parturient and fetus. This product is not easy to develop drug resistance and is not addictive. [indications] can be used for pain, menstrual pain, uterine contraction pain, headache and insomnia caused by digestive system diseases such as stomach, intestine, liver, gallbladder, etc. |
| medication instructions | (1) analgesic effect occurred 10-30 minutes after taking this product for 2-5 hours. It has good analgesic effect on gastrointestinal hepatobiliary system diseases, and poor analgesic effect on severe pain such as trauma. (2) hypnotic and sedative effects are better, taking 100mg at a time and falling asleep 20-30 minutes after taking it for 5-6 hours without any subsequent use. |
| adverse reactions | occasionally dizziness, fatigue or nausea, large doses have a certain inhibitory effect on the respiratory center, and sometimes can cause extrapyramidal symptoms. |
| application note | (1) general treatment amount does not inhibit breathing and there is no addiction, but large dose also has certain inhibitory effect on breathing. (2) Occasionally vertigo, fatigue, nausea, and lethargy, sometimes causing extrapyramidal symptoms. (3) Pregnant women should use it with caution. |
Last Update：2024-04-09 20:49:11
